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Selected Publications & Collaborations

Cox, O., Velez, C., Kumar, V., Malhotra, S., Rivera, L., Hernandez, W., Martinez, J., Cordero, M., Zayas, B. (2014). Synthesis of and Biological Study of 7-Benzyl-3-aminobenzimidazo[3,2-a]quinolinium Chloride (ABQ-48: NSC D-763307) and 7-benzyl-3-nitrobenzimidazo[3,2-a]quinolinium chloride (NBQ 48: NSC D-763303). Current Bioactive Compounds. Vol.10. pp 286-291

Otero,M., Cox,O., Miranda,E., Hernandez, W.J., Velez,C., Zayas,B. (2014) Immunomodulatory response of the unnatural alkaloid,3-amino-7-benzylbenzimidazo[3,2-a] quinolinium chloride (ABQ-48: NSC D-763307) and 3-nitro-7-benzybenzylbenzimidazo[3,2-a]quinolinium chloride (NBQ-48: NSC D -763303). Submitted 03/20015¬† ‚Äď approved/ under final review Journal of Cancer Research and Therapeutics.

Soto, J., Velez, C., Cox, C., Hernandez, W., Rios, K., Zayas, B. (2014). Synthesis and biological mechanism of novel nitro and amino substituted benzazolo[3,2-a]quinolinium salts.  manuscript under preparation*

Silva-Torres, L.A., Velez, C., Alvarez, L., Zayas, B. ( 2014) Xylazine as a Drug of Abuse and Its Effects on the Generation of Reactive Species and DNA Damage on Human Umbilical Vein Endothelial Cells. Hindawi Publising Corporation: Journal of Toxicology Volume 2014, Article ID 492609, 8 pages

Velez, C., Zayas, B., Kumar, A. (2014) Biological Activity of N-Hydroxyethyl-4-aza-2,3-didehydropodophyllotoxin Derivatives upon Colorectal Adenocarcinoma Cells. Open Journal of Medicinal Chemistry, 4,1-11.

Thakur,A., Manohar,S., Velez-Gerena,C.E, Zayas, B., Kumar, V., Malhotra, S.V., Rawat, D.S (2014) Novel 3,5-bis(arylidiene)-4-piperidone based monocarbonyl analogs of curcumin: anticancer activity evaluation and mode of action study. The Royal Society of Chemistry. DOI: 10.1039/c3md00399j

Kulangara Kandi, S., Mahonar,S., Velez Gerena,C.E., Zayas, B., Malhotra,S.V., Rawat,D.S.(2014) C5-curcuminoid-4-aminoquinoline based molecular hybrids: design, sythesis and mechanistic investigation of anticancer activity. The Royal Society of Chemistry. DOI: 10.1039/c4nj00936c

Mahonar,S., Pepe,A., Velez Gerena,C.E., Zayas,B., Malhotra,S.V., Rawat,D.S.(2014) Anticancer activity of 4-aminoquinoline-triazine based molecular hybrids. The Royal Society of Chemistry. DOI: 10.1039/c3ra45333b.

Malhotra,S.V., Kumar,V., Velez,C., Zayas, B. (2014). Imidazolium-derived ionic salts induce inhibition of cancerous cell growth through apoptosis. The Royal Society of Chemistry. DOI: 10.1039/medchemcomm

Vélez, C., Cox, O.,  Rosado-Berrios, C., Molina, D.,  Arroyo, L.,   Carro, S., Kumar, V., Malhotra, S., Cordero, M. and Zayas, B. (2013). Novel nitrobenzazolo[3,2-a]quinolinium salts induce cell death through a mechanism involving DNA damage, cell cycle changes, and mitochondrial permeabilization. Open Journal of Apoptosis, v. 2, 13-22.

Alegria,A.E., Sanchez-Cruz P, Kumar, A., Garcia, C., Gonzalez, F.A., Orellano, A., Zayas, B. and Gordaliza, M. (2008) Thiols oxidation and covalent binding of BSA by cyclolignanic quinones are enhanced by the magnesium cation. Free Radic Res. Jan; 42(1):70-81.

Colón,I.G., Gonzalez,F.A., Cordero,M.,Zayas,B., Velez,C., Cox,O., Kumar,A., and Alegria,A.(2008) Role of the Nitro Functionality in the DNA Binding of 3-Nitro-10-Methylbenzothiazolo [3,2-a] quinolinium Chloride. Chem Research Tox. 21, 1706-1715.

Hillier, S.M., Marquis,J.C., Zayas, B., Wishnok, JS, Liberman RG, Skipper PL, Tannenbaum SR, Essigmann,J.M. &  Croy, R.G. ( 2006) DNA adducts formed by a novel antitumor agent 11beta-dichloro in vitro and in vivo. Mol Cancer Ther. Apr; 5(4): 977-84.

Mitra, K., Marquis, J.C., Hillier, S.M., Rye, P.T., Zayas, B., Lee, A.S., Essigmann, J.M., Croy, R.G., (2002) A rationally designed genotoxin that selectively destroys estrogen receptor-positive breast cancer cells. J Am Chem Soc.Mar6; 124(9): 1862-3.

Zayas, B., Beyley, J.,Terron, M., Cordero, M., Hernandez, W., Alegría, A.E.  & Cox, O. (2007) Comparison of the nucleic acid covalent binding capacity of two nitro substituted benzazolo [3, 2-a] quinolinium salts upon enzymatic reduction. Toxicology In vitro 21(6):1155-64

We are at the present collaborating with:
Miguel Otero Ph.D (Medical Science Campus, University of Puerto Rico)
Oliva Primera-Pedrozo Ph.D (School of Science and Technology, Universidad Metropolitana)
Ajay Kumar Ph.D (School of Environmental Affairs, Universidad Metropolitana)

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